Home  >  Products  >  Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)
Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Vascular Endothelial Growth Factor Receptor 2 (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Cat no: V2110-18V6

Supplier: United States Biological
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VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: HUVEC lysate Cellular Localization: Type 1 membrane protein Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: V2110-18V6
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Takahashi, T., et al. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-1-dependent activation of PLC-y and DNA synthesis in vascular endothelial cells. EMBO. 20(11):2768-2778, 2001. (Human, Western Blot, Immunoprecipitation) 2. Rahimi, N., et al. Receptor chimeras indicated that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J. Biol. Chem. 275(22):16986-16992, 2000. (Porcine, Western Blot, Immunoprecipitation) 3. Yang, L., et al. Expansion of myeloid immune suppresor Gr+CD11b cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 6:409-421, 2004. (Murine, Immunohistochemistry)
Additional info: This antibody is specific for VEGR-2. Species Crossreactivity: This antibody reacts with the human protein. Other species have not yet been tested. The immunogen used for this antibody production has 100% homology with mouse, rat and human proteins.

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