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Vav, phosphorylated (Tyr174) (Proto-oncogene VAV, Vav 1 Guanine Nucleotide Exchange Factor, VAV1)

Vav, phosphorylated (Tyr174) (Proto-oncogene VAV, Vav 1 Guanine Nucleotide Exchange Factor, VAV1)

Cat no: V2121-02E

Supplier: United States Biological
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Vav, which is predominantly expressed during adult life, is one of the genetic markers that correlate with the differentiation of the hematopoietic cells. Its functional importance has been extensively studied in T and B cells, in which it appears crucial for both development and functions. In non-lymphoid hematopoietic cells, Vav is mainly involved in the response of mature cells to a variety of stimuli that lead to spatial and temporal reorganization of the actin-based cytoskeleton during proliferation and phagocytosis. Vav acts as a potential target for gene therapy of myeloproliferative disorders. Human Vav gene maps to the chromosome 19 in the region 19p13.2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2121-02E
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Valeria, B. et al. Experimental Cell Research. 306:56-63 (2005).
Additional info: Recognizes human Vav when phosphorylated at Tyr174. Species Crossreactivity: mouse and rat.

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