VEGF-C, Recombinant, Human (Vascular Endothelial Growth Factor-C, VRP, flt4 ligand)

VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine.It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability.VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes.It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors.During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems.Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.Recombinant human VEGF-C is a 13.5kD non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains.Due to glycosylation the protein migrates as a 20.0-22.0kD band under non-reducing condition.\n\nBiological Activity:\nDetermined by its ability to support rat Retinal Ganglion Cells (RGC-5) cell growth in low serum media.\n\nAA Sequence:\nMAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR\n\nQuality Control:\nVerified by N-terminal and Mass Spectrometry analyses (when applicable).\n\nEndotoxin:\n<0.1ng/ug of protein (<1EU/ug).\n\nProtein Content:\nVerified by UV Spectroscopy and/or SDS-PAGE gel.\n\nStorage and Stability:\nStore lyophilized products at -20 degrees C. For reconstituted solutions of most products, we recommend short-term storage at 4 degrees C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20 degrees C. Additional freeze/thaw cycles may cause some denaturation of the protein.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts