VEGF (Vascular Endothelial Growth Factor, Vascular Permeability Factor, VEGFA, VPF)

VEGF (Vascular Endothelial Growth Factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeablility inducing properties specific for the vascular endothelium. Multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues have been described which arise from alternative splicing of a single gene. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell-associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.\n\nApplications:\nSuitable for use in Neutralization of the bioactivity of human VEGF. Other applications have not been tested.\n\nRecommended Dilution:\nNeutralization: Azide removal is required prior to use.\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: \nAngiosarcoma\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

V2110-13

Size

500ul

Hosts

Mouse

Reactivities

Hum, Rabbit

Form

Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, before the addition of glycerol to 40%. Available without BSA and sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Bobcock, C.A., et al., Journal of the National Cancer Institute 87(7): 506-516 (1995). 2. Brown, L.F., et al., Human Pathology 26(1): 86-91 (1995).

Additional Info

Recognizes human Vascular Endothelial Growth Factor (VEGF). Epitope has not been determined. Species Crossreactivity: Rabbit.