VEGFR2 (CD309, VEGFR, FLK1, VEGFR2, FLK1, Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1)

VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. VEGF receptor 2 is a member of a receptor tyrosine kinase family.Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues.\n\nUniProt Number:\nHuman(P35968), Mouse(P35918), Rat(O08775)\n\nGene ID:\nKDR\n\nApplications:\nSuitable for use in Immunohistochemistry (Frozen).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

145353

Size

100ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Ascites, supplied as a lyophilized powder. Reconstitution: 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

P Type

Mab

Isotype

IgG1

References

1. Folkman, J. : Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1: 27-31, 1995.\n2. Millauer, B.; Shawver, L. K.; Plate, K. H.; Risau, W.; Ullrich, A. : Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576-579, 1994.

Additional Info

Recognizes human VEGFR2. No crossreactivity with other proteins.