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Venturicidin B (Aabomycin A2)

Cat no: V2121-47D


Supplier: United States Biological
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The macrolide antibiotic Venturicidin B, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Originally isolated as an antifungal agent. Purity: >95% by HPLC Solubility: Soluble in ethanol, methanol, DMF or DMSO. Related to: Venturicidin A
Catalogue number: V2121-47D
Size: 250ug
Purity: >95% by HPLC
Alternative names: Aabomycin A2
References: 1. Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. Miedema H. et al. Biochem. Biophys. Res. Commun. 1994, 203, 1005. 2. Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. Matsuno-Yagi A. & Hatefi Y. J. Biol. Chem. 1993, 268, 6168. 3. Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. Galanis M. et al. FEBS Lett. 1989, 249, 333.

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