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VH1-Related Phosphatase, Vaccinia Virus (VHR, DUSP3)

VH1-Related Phosphatase, Vaccinia Virus (VHR, DUSP3)

Cat no: V2210-02

Supplier: United States Biological
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Vaccinia Virus VH1-related phosphatase (VHR), also known as dual-specificity phosphatase 3 (DUSP3), dephosphorylates a variety of substrates at serine, threonine, and tyrosine residues. VHR has been shown to dephosphorylate the mitogen-activated protein kinases ERK1, ERK2, and JNK, but not p38. Phosphorylation of VHR at Y138 by ZAP70 enhances the inhibition of ERK2, suggesting a role for VHR in modulating T-cell receptor signaling. Applications: Suitable for use in Immunohistochemistry and ELISA. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 25ug/mL to detect VHR in paraffin-embedded human tonsil tissue sections. ELISA (Direct): 0.5-1ug/ml.The detection limit for rhVHR is ~1ng/well. Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: V2210-02
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Ishibashi, T. et al., 1992, Proc. Natl. Acad. Sci. USA 89:12170. 2. Todd, J.L. et al., 1999, J. Biol. Chem. 274:13271. 3. Alonso, A. et al., 2003, Nat. Immunol. 4:44.
Additional info: Recognizes human VHR.

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