Virginiamycin Complex (Virginiamycin M1, Virginiamycin S1, Cebin V, Eskalin V, Eskamicin, Stafac, Stephylomycin, Mikamycin, Ostreogrycin, Patricin, Pristinamycin, Streptogramin, Vernamycin)

Virginiamycin complex is defined as a mixture of 75% virginamycin M1 (ostreogrycin A) and 25% virginiamycin S1 and the less abundant S analogs. As the two major components have quite different solubilities these proportions are not readily achieved or used. The individual components are isolated and re-combined to provide the defined components of virginiamycin complex. The structure composition of the complex is important as Virginiamycin S1 acts a synergist binding to the conformational change induced by ostreogrycin A of the peptidyl transferase center of the 50S ribosome.\n\nSource:\nVirginiamycin Complex\n\nMolecular Weight:\n~525.6-823.9\n\nSolubility:\nSoluble DMF or DMSO. Viriginiamycin M1 has only limited solubility in ethanol and methanol.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

V2123-59

Size

5mg

Form

Supplied as a white solid.

Purity

(same/more than) 95% by HPLC (75% Virginamycin M1, 20% Virginiamycin S1, ~5% Other minor\nanalogs)

References

1. The structures of the minor components of virginiamycin S. Vanderhaeghe, H., et al., Tet. Lett. 2687 (1971). 2. Virginiamycin: nomenclature. Crooy, P. and De Neys, R.J., Antibiot. 25: 371 (1972). 3. Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. Porse, B.T., and Garrett, R.A., J. Mol. Biol. 286: 375 (1999).

Alternative Names

Cebin V, Eskalin V, Eskamicin, Stafac, Stephylomycin, Mikamycin, Ostreogrycin, Patricin, Pristinamycin, Streptogramin, Vernamycin