Vitronectin (Vitronectin V10 Subunit, Vitronectin V65 Subunit, VN, VNT, VTN, Complement S Protein, Epibolin, S Protein, S-Protein, Serum Spreading Factor, Somatomedin B, Somatomedin-B, V75)

Vitronectin, also known as serum spreading factor, a 75kD abundant secreted protein found in blood plasma and the extracellular matrix (ECM), involved in cell adhesion, and implicated in signal transduction and cell migration (metastasis) of cancer cells. Vitronectin acts as a regulator of plasminogen activated proteolysis, by binding via its N-terminal somatomedin B domain to plasminogen activator inhibitor-1 (PAI-1), thereby stabilizing it. Vitronectin also uses this N-terminal domain to interact with urokinase receptor, another factor in the plasminogen activation system. In addition, vitronectin contains an RGD (Arginine-Glycine-Aspartic acid) sequence, which acts as a binding site for membrane-bound integrins.\n\nApplications: \nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry: frozen sections\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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