Von Hippel-Lindau Protein, aa1-154, beta Domain, Recombinant, Human, His-tag (vHL)

Von Hippel-Lindau disease (vHL) is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. vHL syndrome is caused by germline mutation in the vHL tumor suppressor, and vHL tumors are associated with loss or mutation of the remaining wild-type allele. vHL has two domains: a roughly 100-residue NH2-terminal domain rich in beta sheet (beta-domain) and a smaller alpha-helical domain (alpha-domain), held together by two linkers and a polar interface. vHL protein is also involved in the degradation of hypoxia-inducible factor (HIF).\n\nMolecular Weight: 19.2kD (174 amino acids)\n\nSequence: MGSSHHHHHH/ SSGLVPRGSH/ MPRRAENWDE/ AEVGAEEAGV/ EEYGPEEDGG/ EESGAEESGP/ EESGPEELGA/ EEEMEAGRPR/ PVLRSVNSRE/ PSQVIFCNRS/ PRVVLPVWLN/ FDGEPQPYPT/ LPPGTGRRIH/ SYRGHLWLFR/ DAGTHDGLLV/ NQTELFVPSL/ NVDGQPIFAN/ ITLP\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

V2640-15

Size

250ug

Form

Supplied as a liquid in PBS, 2mM EDTA, pH 7.4.

Purity

Purified by conventional chromatography techniques ((same/more than) 95% by SDS PAGE).

References

1. Latif, F., et al., Science 260(5112): 1317-1320 (1993). 2. Duan, D.R., et al., Proc. Natl. Acad. Sci. USA 92(14): 6459-6463 (1995). 3. Maxwell, P.H., et al., Nature 399(6733): 271-275 (1999). 4. Stebbins, C.E., et al., Science 284: 455-461 (1999). 5. Staller, P., et al., Nature 425: 307-311 (2003).