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Von Hippel-Lindau Protein (vHL) (BSA & Azide Free)

Cat no: V2640-02X

Von Hippel-Lindau Protein (vHL) (BSA & Azide Free)

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC) and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation. \n\nApplications: \nSuitable for use in ELISA. Other applications not tested. \n\nRecommended Dilutions: \nOptimal dilutions to be determined by the researcher.\n\nSource: \nAscites\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V2640-02X

Size

100ul

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4. No stablizing proteins and no preservatives added. Also available with BSA and azide. See V2640-02.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. Kibel, A., et al., Science 269: 1444-1446 (1995). 2. Corless, C.L., et al., Hum. Path. 28: 459-464 (1997).

Additional Info

Recognizes human von Hippel-Lindau Protein (VHL) at 30kD. Does not recognize the truncated form of VHL protein. Species Crossreactivity: mouse.

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