Von Hippel-Lindau Related Protein (vHL)

Supplier:

United States Biological

Cat no: V2640

Von Hippel-Lindau Related Protein (vHL)

Molecular genetic studies suggest that VHL is a tumor-suppressor gene. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation. \n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nSuggested secondary antibodies: \nI1906 IgY, Chicken Pab Rb x Ch \nI1906-10 IgY, Chicken-HRP Rb x Ch \nI1906-12 IgY, Chicken-FITC Rb x Ch \nI1906-14 IgY, Chicken-AP Rb x Ch

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SPECIFICATIONS

Catalog Number

V2640

Size

1mg

Applications

ELISA

Hosts

Ch/Bird

Reactivities

Hum

Form

Tris buffer, pH 7.4, 0.1% sodium azide

P Type

Pab

Purity

Purified by solvent extraction and column chromatography.

Isotype

IgY

Additional Info

Recognizes Von-Hippel-Landau Related Protein.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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