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Von Willebrand Factor, Factor VIII Free, Human (vWF, Factor VIII Related Antigen)

Cat no: V2651

Von Willebrand Factor, Factor VIII Free, Human (vWF, Factor VIII Related Antigen)

Multimeric Structure of von Willebrand Factor: Each vWF monomer (Mr = 260kD) contains a Factor VIII binding site near the NH2-terminal end of the molecule. The monomers are joined end-to-end (NH2 to NH2 and COOH to COOH) by disulfide bonds to form large multimers. The mature multimers can bind one Factor VIII molecule per monomeric subunit. \n

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SPECIFICATIONS

Catalog Number

V2651

Size

100ug

Form

Supplied as a liquid in 25mM sodium citrate, 100mM glycine, 100mM sodium chloride, pH 6.8.

Purity

(same/more than)95% pure by SDS-PAGE under reducing conditions. Consists of large multimers as determined by electrophoresis in SDS/agarose gels.

References

1. Hoyer, L.W., Blood 58: 1 (1981). 2. Ruggeri, Z.M. & Zimmerman, T.S., J. Clin. Invest. 65: 1318 (1980). 3. Zimmerman, T.S., et al., Proc. Natl. Acad. Sci. USA 72: 5121 (1975). 4. Hoyer, L.W. & Shainoff, J.R., Blood 55: 1056 (1980). 5. Counts, R.B., et al., J. Clin. Invest. 62: 702 (1979). 6. Perret, B.A., et al., Biochim. Biophys. Acta 578: 164 (1979). 7. Weinstein, M. & Deykin, D., Blood 53: 1095 (1979). 8. Meyer, D., et al., J. Lab. Clin. Invest. 95: 590 (1980). 9. Okumura, T. & Jameison, G.A., Thromb. Res. 8: 701 (1976). 10. Nachman, R.L., et al., J. Clin. Invest. 59: (1977). 11. Jenkins, C.S.P., et al., J. Clin. Invest. 57: 112 (1976).

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