Home  >  Products  >  WASP, phosphorylated (Ser484) (Wiskott Aldrich Syndrome Protein, Wiskott-Aldrich Syndrome (Eczema Thrombocytopenia) Protein, WAS Protein, IMD2, Thrombocytopenia 1 (X-linked), THC1, THC)

WASP, phosphorylated (Ser484) (Wiskott Aldrich Syndrome Protein, Wiskott-Aldrich Syndrome (Eczema Thrombocytopenia) Protein, WAS Protein, IMD2, Thrombocytopenia 1 (X-linked), THC1, THC)

Cat no: W0800-20D


Supplier: United States Biological
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The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W0800-20D
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Tris-citrate/phosphate, pH 7 to 8
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Species Crossreactivity: Human. Reactivity with mouse WASP phosphorylated at the residues corresponding to S483 and S484 of human WASP is likely owing to conservation of sequence between human and mouse WASP in the vicinity of these residues.

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