Wee1 Antibody

Cat no: 252157

Supplier: ABBIOTEC

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Description
Additional Information

Wee1 acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-comple, Xenopus/Amphibian,ed CDK1 before the onset of mitosis. The activity of wee1 increases during the S and G2 phases, and decreases in M phase when it is hyperphosphorylated. A correlated decrease in wee1 protein level occurs at M/G1 phase,Porcinerobably due to its degradation. Wee1 specifically phosphorylates and inactivates cyclin B1-comple, Xenopus/Amphibian,ed CDK1 reaching a ma, Xenopus/Amphibian,imum during G2 phase and a minimum as cells enter M phase. The phosphorylation of cyclin B1-CDK1 occurs e, Xenopus/Amphibian,clusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur.

Catalogue number:	252157
Reactivities:	Human, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P30291
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human wee1.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Wee1-like protein kinase; WEE1hu; Wee1A kinase; WEE1