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West Nile Virus, Core, CT (WNV Core, Capsid Protein C)

West Nile Virus, Core, CT (WNV Core, Capsid Protein C)

Cat no: W1018-40D

Supplier: United States Biological
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WNV belongs to the Flaviviridae family which includes closely viruses such as Dengue fever, Yellow fever and Tick borne encephalitis. West Nile Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope containing envelope and matrix proteins. Research indicates that the viral core protein contributes to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway. West Nile Virus is believed to have originated in the West Nile region of Africa and has now spread to Europe, Asia and America where it has become a significant disease affecting human and domestic animal health. Applications: Suitable for use in ELISA, Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1ug/ml Immunofluorescence: 20ug/ml Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: W1018-40D
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Gould, L.H., et al (2004) West Nile virus: a growing concern. J.Clin. Invest. 113:1102-1107 2. Chu, J.J., et al (2005) Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein. J. Gen. Virol. 86:405-12 3. Chu, J.J., et al (2004) Interaction of West Nile virus with a v b 3 integrin mediates virus entry into cells. J. Biol. Chem. 2004; 279:54533-41. 4. Yang, J.S., et al (2002) Induction of inflammation by West Nile Virus capsid through the caspase-9 apoptotic pathway. Emerg. Infect. Dis. 8:1379-84.
Additional info: Recognizes the 14kD core protein of West Nile Virus (WNV).

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