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West Nile Virus, Core, CT (WNV Core, Capsid Protein C)

West Nile Virus, Core, CT (WNV Core, Capsid Protein C)

Cat no: W1018-40F

Supplier: United States Biological
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West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein (MW 13kD) is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase- 9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation. Applications: Suitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: W1018-40F
Hosts: Rabbit
Applications: ELISA, Immunocytochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Gould, LH. et al. J. Clin. Invest. 113, 1102 (2004). 2. Chu, JJ. et al. J. Gen. Virol. 86, 405 (2005). 3. Chu, JJ. et al. J. Biol. Chem. 279, 54533 (2004). 4. Yang, JS. et al. Emerg. Infect. Dis. 8, 1379 (2002).
Additional info: Recognizes West Nile Virus Core.

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