Home  >  Products  >  WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin, DFNA14, DFNA38, DFNA6, DIDMOAD)
WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin, DFNA14, DFNA38, DFNA6, DIDMOAD)

WFS1 (Wolfram Syndrome 1 (Wolframin), Wolfram Syndrome, WFRS, WFS, Wolframin, DFNA14, DFNA38, DFNA6, DIDMOAD)

Cat no: W1023-70

Supplier: United States Biological
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WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:2000. Heat samples at 50 degrees C for 30 minutes. Immunoprecipitation: 2ul Immunofluorescence: 1:200 Immunohistochemistry (Frozen): 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: W1023-70
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Fonseca, SG, et al. J. Biol. Chem. 280: 39609-39615 (2005). 2. Takeda, K, et al. Hum Mol Gen. 10: 477-484 (2001).
Additional info: Recognizes human WFS1 protein at ~100kD. Species crossreactivity: mouse and rat.

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