According to Chen TR, 1987, the WiDr cell line is a derivative of the HT-29 cell line. HT29 was isolated from a primary colon adenocarcinoma in a 44-year-old Caucasian female. The cells are negative for Colon Antigen 3 expression, but positive for keratin by immunoperoxidase staining. The cells expressed p53 antigen (the p53 produced has a G-A mutation resulting in Arg-His at position 273). Growth of WiDr cells is inhibited by tumor necrosis factor alpha (TNF Inhibitors of dihydrofolate reductase are highly cytotoxic to WiDr cells). WiDr were also described to express epidermal growth factor (EGF).
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