Wilms Tumor

Supplier:

United States Biological

Cat no: W1125-85

Wilms Tumor

Wilms Tumor (WT) is a 55kDa protein thought to play a major role in various cancers and developmental disorders, commonly kidney tumors and glomerular diseases. WT is a zinc finger transcription factor that is mutated in Wilms tumors and highly expressed in a wide variety of other malignancies (1). It is believed that WT in its two isoforms acts as both a transcription factor and a post-transcriptional regulator that binds RNA and can interact with splicing components (2). Mutations in the zinc finger regions of WT are detected in nearly all patients of Denys-Drash syndrome and in some patients with isolated diffuse mesangial sclerosis. Also, mutations leading to the loss of the transcription factor isoform have been observed in all patients with Frasier syndrome (3).\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000-1:5000\nImmunohistochemistry: 1:100- 1:250\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. \n\nManufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

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SPECIFICATIONS

Catalog Number

W1125-85

Size

100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 50 mM Tris-Glycine (pH 7.4), 0.18M sodium chloride, 40% glycerol, 0.25mM sodium azide, 0.25mM EDTA, 25mM citric acid and 0.5% BSA.

P Type

Mab

Purity

Supernatant

Isotype

IgG

References

1.Spraggon L, et al. Oncogene. Aug 21, 2006 2.Markus MA, et al. Exp Cell Res. 2006 Jul 25 3.Niaudet P, et al. Pediatr Nephrol. 2006 Aug 23

Additional Info

Recognizes human Wilms Tumor. Does not cross-react with mouse and rat by Western Blot.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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