Supplier:
Alomone Labs Ltd.Cat no: GPW-105
WKYMVm
Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). In human, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to the G\\i\\ subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca2+increase.
WKYMVm is a selective agonist of the Formylpeptide receptors (FPR2 and FPR3) and was discovered by screening peptide libraries for their ability to stimulate inositol phosphates in lymphocyte cell lines. FPR2 is expressed in the promyelocytic leukemia cell line HL-60 as well as in the chronic myelogenous leukemia cell line K562.
WKYMVm inhibited the infection of human peripheral monocyteпїЅderived macrophages and CD41 T lymphocytes by strains of HIV-1, via sensitization of chemokine receptors (CXCR4 and CCR5), following FPR2 activation. G-Protein Coupled Receptor Ligands; Formylpeptide Receptor Ligands.
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SPECIFICATIONS
Catalog Number
GPW-105
Size
1 mg
Purity
>98%
Concentration
1 nM - 10 uM
Shipping Temp
Room Temperature
Molecular Weight
856.11 da
SUPPLIER INFO
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