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WNK4 (mouse) Antibody

WNK4 (mouse) Antibody

Cat no: 250912


Supplier: ABBIOTEC
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Ser/Thr-protein kinase WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation, which prevents membrane trafficking of SLC12A3. WNK4 also inhibits the renal potassium channel KCNJ1 via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 acts as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. WNK4 is e, Xenopus/Amphibian,clusively present in intercellular junctions in th edistal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. Defects in WNK4 are a cause of pseudohypoaldosteronism type II (PHAII).
Catalogue number: 250912
Reactivities: Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: Q96J92
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse WNK4.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: WNK4; Ser/Thr-protein kinase WNK4; Serine/threonine-protein kinase WNK4; protein kinase with no lysine 4; protein kinase, lysine
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