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Wnt1 (Proto-oncogene Wnt-1, Proto-oncogene Int-1 Homolog, INT1)

Wnt1 (Proto-oncogene Wnt-1, Proto-oncogene Int-1 Homolog, INT1)

Cat no: W3006-02D

Supplier: United States Biological
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Wnt1, a 370aa protein belonging to the Wnt family, is a signaling molecule important in CNS development. It plays a role in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt1 signaling is involved in many functions including the inhibition of apoptosis in several cancers, inhibition of interfollicular progenitor cell growth and it promotes terminal differentiation of keratinocytes and plays a role in angiogenesis by endothelial cell growth control that is mediated through cell-cell contact. Wnt1 blockade by either monoclonal antibody or siRNA induces cell death in sarcoma cells. It is expressed in hair follicles, sebaceous glands, skin and other tissues. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: W3006-02D
Reactivities: Human, Rat, Bovine, Canine, Non-Human Primate
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Cheng, CW. et al. Exp. Cell. Res. 291:415-425 (2003).
Additional info: Recognizes human Wnt1/Int1. Species Crossreactivity: bovine, canine, equine, monkey, opossum, rat. Species sequence homology: pufferfish, zebrafish.

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