Home  >  Products  >  Wnt3 (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member 3, Wnt 3, Wnt-3, Wnt 3 Proto-oncogene Protein, Wnt3 Proto-oncogene Protein, Wnt-3 Proto-oncogene Protein Precursor, Int4, MGC131950, MGC138321, MGC138323)
Wnt3 (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member 3, Wnt 3, Wnt-3, Wnt 3 Proto-oncogene Protein, Wnt3 Proto-oncogene Protein, Wnt-3 Proto-oncogene Protein Precursor, Int4, MGC131950, MGC138321, MGC138323)

Wnt3 (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member 3, Wnt 3, Wnt-3, Wnt 3 Proto-oncogene Protein, Wnt3 Proto-oncogene Protein, Wnt-3 Proto-oncogene Protein Precursor, Int4, MGC131950, MGC138321, MGC138323)

Cat no: W3035-55

Supplier: United States Biological
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The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Peptide ELISA: Antibody detection limit dilution 1:2,000. Western Blot: 1-3ug/ml; Approx 38kD band observed in Human Brain lysates (calculated MW of 39.6kDa according to NP_110380.1). Optimal dilutions to be determined by the researcher. Positive Control: Human Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W3035-55
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Schmitt AM, Shi J, Wolf AM, Lu CC, King LA, Zou Y. , Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping. ,Nature. 2006 Jan 5;439(7072):31-7. , PMID: 16280981
Additional info: Recognizes human WNT3.

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