Wnt5A is a nontransforming member of the Wnt family of secreted and cysteine-rich proteins that exert their cellular effects via autocrine or paracrine routes. It is a proto-oncogene that functions in modulating cell fate and cell behavior during vertebrate development and has an important role in the Wnt signaling pathway. It acts as a ligand for members of the frizzled family of seven transmembrane receptors. The protein also plays a role in preventing metastatic disease in invasive breast carcinomas. The protein has many conserved features like a hydrophobic signal sequence, Wnt1 family signature sequence (CKCHGvSGSC), and a number of other conserved aa residues. Human Wnt5A expression was detected only in neonatal heart and lung. The gene for human Wnt5A is localized on chromosome 3p21-p14.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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