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Products Wortmannin (KY 12420, BRN 0067676, NSC 627609, Antibiotic SL-2052)
| Catalogue number: | 045393 |
| Size: | 1mg |
| Purity: | >98% (HPLC) |
| Alternative names: | KY 12420, BRN 0067676, NSC 627609, Antibiotic SL-2052 |
| References: | Product Reference: ?Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil: R.W. Bonser, et al.; Br. J. Pharmacol. 103, 1237 (1991) ?Wortmannin, a microbial product inhibitor of myosin light chain kinase: S. Nakanishi, et al.; J. Biol. Chem. 267, 2157 (1992) ?Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses: A. Arcaro & M.P. Wyman; Biochem. J. 296, 297 (1993) ?Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase: G. Powis, et al.; Cancer Res. 54, 2419 (1994) ?Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase: G.I. Welsh, et al.; Biochem. J. 303, 15 (1994) ?In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin: R.M. Schultz, et al.; Anticancer Res. 15, 1135 (1995) ?Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells: K. Tomiyama, et al.; BBRC 212, 263 (1995) ?The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage: B.D. Price & M.B. Youmell; Cancer Res. 56, 246 (1996) ?Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells: S. Boulton, et al.; Carcinogenesis 17, 2285 (1996) ?Potent inhibition of angiogenesis by wortmannin, a fungal metabolite: T. Oikawa & M. Shimamura; Eur. J. Pharmacol. 318, 93 (1996) ?Wortmannin, a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages: Y.C. Park, et al.; BBRC 240, 692 (1997) ?The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes: E.F. Blommaart, et al.; Eur. J. Biochem. 243, 240 (1997) ?Wortmannin, a potent antineutrophil agent, exerts cardioprotective effects in myocardial ischemia/reperfusion: L.H. Young, et al.; J. Pharmacol. Exp. Ther. 295, 37 (2000) ?DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells: N.G. Oliveira, et al.; Teratog. Carcinog. Mutagen. 22, 343 (2002) ?Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin: S.J. Liu & J.Z. Wang; Acta Pharmacol. Sin. 23, 183 (2002) ?Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase: Y. Liu, et al.; Chem. Biol. 12, 99 (2005) ?Chemistry and biology of wortmannin: P. Wipf & R.J. Halter; Org. Biomol. Chem. 3, 2053 (2005) ? |
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