Home  >  Products  >  WRN, aa1400-1432 (Werner, RECQ3, RECQL2, RECQL3, Werner Syndrome Helicase, Werner Syndrome Protein, HGNC:12791)
WRN, aa1400-1432 (Werner, RECQ3, RECQL2, RECQL3, Werner Syndrome Helicase, Werner Syndrome Protein, HGNC:12791)

WRN, aa1400-1432 (Werner, RECQ3, RECQL2, RECQL3, Werner Syndrome Helicase, Werner Syndrome Protein, HGNC:12791)

Cat no: W9000-02A

Supplier: United States Biological
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WRN (Werner syndrome helicase/protein), a nucleolar DNA helicase and member of the RecQ subfamily which contains a functional exonuclease domain (WRN-exo), and is implicated in DNA double-strand break repairs, through interaction with Ku70/80. Defects in the WRN gene are responsible for the rare autosomal recessive premature ageing disease known as Werner syndrome, characterized by age-related disorders including atherosclerosis, osteoporosis, non-insulin-dependent diabetes mellitus, ocular cataracts and cancer. Applications: Suitable for use in Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Immunoprecipitation: 2-5ug/mg lysate Western Blot: 1:5000-1:25,000, detects a band of ~200kD in 293T whole cell lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W9000-02A
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid Tris-citrate/phosphate and 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Li, B. and Comai, L. (2001) Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex. J. Biol. Chem. 276: 9896-9902. 2. Huang, S. et al. (2006) The spectrum of WRN mutations in Werner syndrome patients. Hum. Mutat. 27: 558-567.
Additional info: Specifically recognizes human WRN (Werner syndrome helicase/protein).

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