Home  >  Products  >  WRN (Werner Syndrome Helicase, Werner's Syndrome Helicase WRN, Werner Syndrome Protein, HGNC:12791, RECQ3, RECQL2, RECQL3)
WRN (Werner Syndrome Helicase, Werner's Syndrome Helicase WRN, Werner Syndrome Protein, HGNC:12791, RECQ3, RECQL2, RECQL3)

WRN (Werner Syndrome Helicase, Werner's Syndrome Helicase WRN, Werner Syndrome Protein, HGNC:12791, RECQ3, RECQL2, RECQL3)

Cat no: W9000-01B

Supplier: United States Biological
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This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner Syndrome, an autosomal recessive disorder characterized by premature aging. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot (ECL): 1:5000-1:25,000 Immunoprecipitation: 2-5ug/mg lysate Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: W9000-01B
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7.5, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Harrigan JA, Piotrowski J, Di Noto L, Levine RL, Bohr VA. J Biol Chem. 282(50): 36403-11 (2007). 2. Nyunoya T, Monick MM, Klingelhutz AL, et al. Am J Respir Crit Care Med 2008:200802-200320OC.
Additional info: Recognizes human WRN. Does not crossreact with mouse.

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