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WWOX, 1-234aa, Recombinant, Human (WWOX, WW domain containing oxidoreductase, HGNC:12799, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, WWOX v8, FOR II protein, WW domain-containing oxidoreductase, WW domain-containing protein WWOX, fragile 16D oxido reductase

Cat no: W9100-12

WWOX, 1-234aa, Recombinant, Human (WWOX, WW domain containing oxidoreductase, HGNC:12799, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, WWOX v8, FOR II protein, WW domain-containing oxidoreductase, WW domain-containing protein WWOX, fragile 16D oxido reductase

WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death.\n\nSource:\nRecombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli.\n\nMolecular Weight: 28.3kD (254aa)\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MSDIEEVVEE YEEEEQEEAA VEEQEEAAEE DAEAEAETEE TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI RNEREKERQN RLAEERARRE \nEEENRRKAED EARKKKALSN MMHFGGYIQK TERKSGKRQT EREKKKKILA ERRKVLAIDH LNEDQLREKA KELWQSIYNL EAEKFDLQEK FKQQKYEINV LRNRINDNQK VSKTRGKAKV TGRWK\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

W9100-12

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH8.0, 10% glycerol.

Purity

(same/more than)90% (SDS-PAGE)

References

1. Bouteille N., et al. (2009), Oncogene. 28(28):2569-80. 2. Gourley C., et al. (2009). Cancer Res. 69(11):4835-42.

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