Home  >  Products  >  WWOX (WW Domain Containing Oxidoreductase, WW Domain-containing Protein WWOX, D16S432E, FOR, FOR II Protein, Fragile 16D Oxido-reductase, Fragile Site FRA16D Oxidoreductase, FRA16D, HGNC:12799, HHCMA56, PRO0128, Putative Oxidoreductase, WOX1)
WWOX (WW Domain Containing Oxidoreductase, WW Domain-containing Protein WWOX, D16S432E, FOR, FOR II Protein, Fragile 16D Oxido-reductase, Fragile Site FRA16D Oxidoreductase, FRA16D, HGNC:12799, HHCMA56, PRO0128, Putative Oxidoreductase, WOX1)

WWOX (WW Domain Containing Oxidoreductase, WW Domain-containing Protein WWOX, D16S432E, FOR, FOR II Protein, Fragile 16D Oxido-reductase, Fragile Site FRA16D Oxidoreductase, FRA16D, HGNC:12799, HHCMA56, PRO0128, Putative Oxidoreductase, WOX1)

Cat no: W9100-11C

Supplier: United States Biological
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WW domain-containing oxidoreductase (WWOX) is a proapoptotic protein and a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33-phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: W9100-11C
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified
References: 1. Chang, N.S., et al. Oncogene 24(4): 714-723 (2005). 2. Aqeilan, R.I., et al. Cancer Res. 64(22): 8256-8261 (2004). 3. Sze, C.I., et al. J. Biol. Chem. 279(29): 30498-30506 (2004). 4. Chen, S.T., et al. Neuroscience 124(4): 831-839 (2004).
Additional info: Reacts with human, mouse, chimpanzee and orangutang.

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