X-box binding protein 1 (XBP1; also tax-responsive element-binding protein 5 (TREB5)) is a ubiquitously expressed 38kD member of the bZIP family of proteins. Human XBP1 is 261aa in length, and contains a basic motif (aa72-94), which serves as a DNA binding site, followed by a leucine-zipper domain (aa98-126). A splicing variant in isoform 1 of XBP1 produces a second isoform, which has a 210aa substitution for aa 161-261 in isoform 1. Human XBP1 shares 85%, 79%, and 77% aa sequence identity with bovine, rat, and mouse XBP1, respectively. XBP1 functions as a transcription factor that is essential for hepatocyte growth, plasma cell differentiation, immunoglobulin secretion, and the unfolded protein response.
Applications:
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilution:
Flow Cytometry: 2.5ug pr 10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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