Home  >  Products  >  XAV939 (3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one)

XAV939 (3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one)

Cat no: X0986-25


Supplier: United States Biological
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A Tankyrase (TNKS) inhibitor (IC50 = 110nM for TNKS1 and 4nM for TNKS2). Antagonizes wnt signaling via stimulation of beta-catenin degradation and stabilization of axin. Inhibits proliferation of the mu-catenin-dependent colon carcinoma cell line DLD-1. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Catalogue number: X0986-25
Size: 1mg
Form: Supplied as a white solid. Reconstitute with 50mM DMSO.
Purity: ~98% (HPLC)
Alternative names: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one
References: 1. Huang, S.M., et al. (2009). Nature 461, 614-620.

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