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XIAP, CT (Baculoviral IAP Repeat-containing Protein 4, E3 Ubiquitin-protein Ligase XIAP, IAP-like Protein, ILP, hILP, Inhibitor of Apoptosis Protein 3, IAP-3, hIAP-3, hIAP3, X-linked Inhibitor of Apoptosis Protein, X-linked IAP, API3, BIRC4, IAP3)

Cat no: X1034-10C

XIAP, CT (Baculoviral IAP Repeat-containing Protein 4, E3 Ubiquitin-protein Ligase XIAP, IAP-like Protein, ILP, hILP, Inhibitor of Apoptosis Protein 3, IAP-3, hIAP-3, hIAP3, X-linked Inhibitor of Apoptosis Protein, X-linked IAP, API3, BIRC4, IAP3)

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The X- chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases

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SPECIFICATIONS

Catalog Number

X1034-10C

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Schimmer, AD. et al. Cancer Res. 64, 7183 (2004). 2. Deveraux, QL. et al. Nature 388, 300 (1997). 3. Deveraux, QL. et al. EMBO J. 18, 5242 (1999). 4. Holcik, M. et al. 19, 4174 (2000). 5. Liston, P. et al. Nature Cell Biol. 3, 128 (2001). 6. Du, C. et al. Cell 102, 33 (2000).

Additional Info

Recognizes human XIAP. Species Crossreactivity: mouse.

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