Home  >  Products  >  XLF (XRCC4-like Factor, Cernunnos, FLJ12610, Nonhomologous End Joining Factor 1, Non-homologous End-joining Factor 1, NHEJ 1, NHEJ1, Protein Cernunnos)
XLF (XRCC4-like Factor, Cernunnos, FLJ12610, Nonhomologous End Joining Factor 1, Non-homologous End-joining Factor 1, NHEJ 1, NHEJ1, Protein Cernunnos)

XLF (XRCC4-like Factor, Cernunnos, FLJ12610, Nonhomologous End Joining Factor 1, Non-homologous End-joining Factor 1, NHEJ 1, NHEJ1, Protein Cernunnos)

Cat no: X1042-01E

Supplier: United States Biological
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XLF (also known as Cernunnos) is a DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. It may serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of human skin, testis and thyroid gland on ~38kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: X1042-01E
Reactivities: Human, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Ahnesorg P, Smith P, Jackson SP. XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell. 2006 Jan 27;124(2):301-13.
Additional info: Recognizes human NHEJ1. Species sequence homology: Canine.

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