XPNPEP1 (X-prolyl aminopeptidase (aminopeptidase P) 1, soluble, Aminoacylproline Aminopeptidase, Cytosolic aminopeptidase P, sAmp, SAMP, Soluble aminopeptidase P, Xaa-Pro aminopeptidase 1, XPNPEP, XPNPEPL, X-Pro aminopeptidase 1)

Aminopeptidase P1 (APP1), also known as XPNPEP1 (X-prolyl aminopeptidase), is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Deficiency of X-prolyl aminopeptidase results in excretion of large amounts of imino-oligopeptides in urine. The sequence of human APP1 is 99%, 97%, and 95% identical to that of canine, bovine, and mouse/rat.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32000\nWestern Blot: 0.3-1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

X1049-56B

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J.\nExploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nature biotechnology 2003 May 21 (5): 566-9. PMID: 12665801

Additional Info

Recognizes human XPNPEP1. Sequence Homology: mouse, rat, bovine, porcine, canine.