XRCC2 (X-ray Repair Complementing Defective Repair in Chinese Hamster Cells 2, X-ray Repair Cross-complementing Protein 2, DKFZp781P0919, DNA Repair Protein XRCC2)

XRCC2 is a member of an emerging family of Rad51-related proteins that likely participate in homologous recombination to maintain chromosome stability and repair DNA damage. It is shown to interact directly with HsRad51, and like Rad55 and Rad57 in yeast, may cooperate with HsRad51 during recombinational repair, and thus is important in the early stages of homologous recombination in mammalian cells. The gene was recently identified by its ability to complement a hamster cell line, irs1, which is sensitive to DNA-damaging agents and shows genetic instability. It is highly conserved in mammalian species and has structural features, including a putative ATP-binding domain (P-loop), consistent with membership of the RecA/RAD51 family of recombination-repair proteins.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:25-1:50\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nTestis\n\nCellular Localization: \nCytoplasmic and nuclear\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

X9502-01F

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Johnson et al. Nature 401: 397, 1999. 2. Tambini et al. Genomics 41: 84, 1997. 3. Liu et al. Mol Cell 1: 783, 1998. 4. Paul et al. J Biol Chem 276: 22148, 2001.

Additional Info

Recognizes human XRCC2.