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YMER (Chromosome 3 Open Reading Frame 6, C3orf6, Coiled-coil Domain-containing Protein 50, CCDC50, DFNA44, Protein Ymer)

YMER (Chromosome 3 Open Reading Frame 6, C3orf6, Coiled-coil Domain-containing Protein 50, CCDC50, DFNA44, Protein Ymer)

Cat no: Y2065-15A

Supplier: United States Biological
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YMER is a 306aa soluble cytoplasmic protein associated with microtubules of the cytoskeleton and mitotic apparatus. It has a coiled-coil domain and two motifs interacting with ubiquitin (MIUs). In response to EGF signaling, YMER undergoes tyrosine phosphorylation and ubiquitination and is also involved in the negative regulation of the EGF receptor. It has two isoforms, YMER-L and YMER-S, that are co-expressed in placenta, liver, lung, kidney and pancreas. However, YMER-S, the dominant YMER isoform expressed in human cells, is an inhibitor of EGFR downregulation. Defects in YMER leads to autosomal dominant non-syndromic sensorineural deafness type 44 (DFNA44). YMER shows ubiquitous expression in most of the human tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.05-0.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human, mouse, rat skeletal muscle Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Y2065-15A
Reactivities: Human, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Modamio-Hoybjor, S. et al. Am. J. Hum. Genet. 80:1076-1089 (2007). 2. Modamio-Hoybjor, S. et al. Hum. Genet. 112:24-28 (2003). 3. Tashiro, K. et al. J. Biol. Chem. 281:24612-24622 (2006). 4. Vazza, G. et al. Gene. 314:113-120 (2003).
Additional info: Recognizes human YMER. Species Crossreactivity: chimpanzee, monkey. Species sequence homology: bovine, canine, rat.

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