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Z-Leu-Leu-Leu-CHO, Z-LLL-CHO (MG-132)

Cat no: Z0720-01C


Supplier: United States Biological
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A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50= 3uM). Prevents g-secretase cleavage. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from air and light.
Catalogue number: Z0720-01C
Size: 5mg
Form: Supplied as a liquid in anhydrous 10mM DMSO (5mg in 1051ul).
Purity: ~99% (HPLC)
Alternative names: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO (EZSolutionTM)

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