Home  >  Products  >  Z-VAD-FMK (Cell permeable) (Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone)
Z-VAD-FMK (Cell permeable) (Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone)

Z-VAD-FMK (Cell permeable) (Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone)

Cat no: 045397

Supplier: United States Biological
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Cell-permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3-induced cells. Used in apoptosis and inflammasome studies. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 3 years after receipt when stored at -20 degrees C.
Catalogue number: 045397
Size: 1mg
Purity: >95% (HPLC)
Alternative names: Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone
References: Product Reference: Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32: E.A. Slee, et al.; Biochem. J. 315, 21 (1996) ? Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli: A. Sarin, et al.; J. Exp. Med. 184, 2445 (1996) ? Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells: M. MacFarlane, et al.; J. Cell Biol. 137, 469 (1997) ? Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells: D. King, et al.; Leukemia 12, 1553 (1998)? Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes: J. Beyette, et al.; Biochem. J. 332, 315 (1998)? JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation: M. MacFarlane, et al.; Biochem. J. 348, 93 (2000)? Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes: W.R. Coward, et al.; J. Immunol. 176, 5284 (2006) ? Broad-spectrum caspase inhibitors: from myth to reality? D. Chauvier, et al.; Cell Death Differ. 14, 387 (2007) ? A calpain-like protease inhibits autophagic cell death: D.T. Madden, et al.; Autophagy 3, 519- (2007)? Malarial hemozoin is a Nalp3 inflammasome activating danger signal; C. Dostert, et al.; PLoS One 4, e6510 (2009)?

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