Home  >  Products  >  ZBP1 (Z-DNA binding protein 1, C20orf183, DAI, dJ718J7.3, DLM1, DLM-1, Tumor stroma and activated macrophage protein DLM-1)
ZBP1 (Z-DNA binding protein 1, C20orf183, DAI, dJ718J7.3, DLM1, DLM-1, Tumor stroma and activated macrophage protein DLM-1)

ZBP1 (Z-DNA binding protein 1, C20orf183, DAI, dJ718J7.3, DLM1, DLM-1, Tumor stroma and activated macrophage protein DLM-1)

Cat no: Z0400-03

Supplier: United States Biological
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yZ-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA (1). ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia (2). More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK) (3). Multiple isoforms of ZBP1 are known to exist. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5
Catalogue number: Z0400-03
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Schwartz T, Behlke J, Lowenhaupt K, et al. Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA- binding proteins. Nat. Struct. Biol. 2001; 8:761-5. 2. Fu Y, Comella N, Tognazzi K, et al. Cloning of DLM-1, a novel gene that is up-regulated in active macrophages, using RNA differential display. Gene 1999; 204:157-63. 3. Takaoda A, Wang Z, Choi MK, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007; 448:501-5.
Additional info: Recognizes human ZBP1. Species crossreactivity: Mouse and rat.

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