ZBTB7B (Zinc Finger and BTB Domain-containing Protein 7B, Krueppel-related Zinc Finger Protein cKrox, c-Krox, T-helper-inducing POZ/Krueppel-like Factor, Zinc Finger Protein 67, Zfp-67, Zinc Finger Protein Th-POK, Thpok, Zfp67)

Th-POK is a 62-68kD member of the Krox family of transcription factors. It is expressed in immature T cells where it promotes commitment to the CD4+ T cell lineage. It is also expressed in fibroblasts and chondrocytes where it promotes type I and type II collagen secretion. Human Th-POK is 539aa in length. It contains a BTB/POZ domain aa34-115 that mediates homo- and heterodimerization with hcKROX-b and -g, a Pro-rich segment aa181-196, and four C-terminal C2H2-type zinc finger regions aa346-454. There is one variant that shows a 34aa N-terminal extension. Over aa78-172, human Th-POK is 97% aa identical to mouse Th-POK.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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