Zerumbone ((2E,6E,10E)-2,6,9,9-Tetramethylcycloundeca-2,6,10-trien-1-one)

Size

10mg

References

Product Reference: \n?Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet: T. Tanaka, et al.; Life Sci. 69, 1935 (2001)\n?Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. S. Yodkeeree, et al.; Cancer Res. 69, 6581 (2009) \n?Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells: S.I. Abdelwahab, et al.; Leuk. Res. Epub ahead of print (2010)\n?Antitumor effects of zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo: G.C. Huang, et al.; Planta Med. 71, 219 (2005)\n?Zerumbone, an anti-inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell lines: A. Murakami, et al.; Biofactors 21, 95 (2004)\n?Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice: M. R. Sulaiman, et al.; Fitoterapia 81, 855 (2010)\n?Preliminary analysis of the antinociceptive activity of zerumbone: M. R. Sulaiman, et al.; Fitoterapia 80, 230 (2009)\n?Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells: B. Sung, et al.; Cancer Res. 68, 8938 (2008)\n?Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice: B. Sung, et al.; Cancer Res. 69, 1477 (2009)\n?Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion: Y. Takada, et al.; Oncogene 24, 6957 (2005)\n?