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Zic2 (Zinc Finger Protein of the Cerebellum 2, HPE5, Zic 2, Zic Family Member 2 (Odd-paired Drosophila Homolog), Zinc Finger Protein Zic2, Zinc Finger Protein Zic-2)

Zic2 (Zinc Finger Protein of the Cerebellum 2, HPE5, Zic 2, Zic Family Member 2 (Odd-paired Drosophila Homolog), Zinc Finger Protein Zic2, Zinc Finger Protein Zic-2)

Cat no: Z0422-01C

Supplier: United States Biological
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Zinc finger protein ZIC2 is a member of the GLI C2H2-type zinc-finger protein family. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Gene mutations cause holoprosencephaly type 5 in human brain and neural tube defects. Recent studies show that complete deficiency of the related murine ZIC2 transcription factor can also be a contributing factor to variable midline deficiencies, presenting during mid-gastrulation and similar forebrain anomalies. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 4-7ug/ml Optimal dilutions to be determined by the researcher. Positive Control: HepG2 call lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Z0422-01C
Reactivities: Human, Mouse, Bovine, Canine, Chicken/Bird, Non-Human Primate
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Brown, SA. et al. Nat. Genet. 20:180-183 (1998). 2. Roessler, E. et al. Hum. Mutat. 30:E541-E554 (2009). 3. Yang, Y. et al. J. Biol. Chem. 275:38863-38869 (2000).
Additional info: Recognizes human ZIC2. Species Crossreactivity: chicken, chimpanzee, bovine, canine, equine, monkey, mouse.

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