Zinc-alpha-2-glycoprotein, Recombinant, Human (ZAG, ZA2G, AZGP1, Zn-alpha-2-glycoprotein, Zn-alpha-2-GP, ZNGP1)

Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. It is identical in aa sequence to tumor-derived lipid mobilizing factor (LMF), a protein associated with the dramatic loss of adipose body stores in cancer cachexia, and has been shown to stimulate lipolysis by adipocytes in vivo and in vitro. A role for ZAG has been proposed in the regulation of body weight, and age-dependent changes in genetically influenced obesity, and also it regulates melanin production by normal and malignant melanocytes. It has also recently been classified as a novel adipokine in that it is produced by both white and brown fat adipocytes and may be useful for the study of Diabetes and Obesity.\n\nSource: \nRecombinant corresponding to human Zinc-alpha-2-glycoprotein (ZAG) expressed in E.coli.\n\nMolecular Weight:\n~30.25kD\n\nBiological Activity:\nhe ED50 as determined by the dose-dependant induction of IL-6 in primary human foreskin fibroblasts was found to be 2ng/ml, corresponding to a specific activity of 5x105units/mg. \n\nSequence:\nGly-Ile-Thr-Ile-Pro\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.human

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