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ZIPK, Control Peptide (ZIPtide, Zip Kinase)

Cat no: Z0550-01A

ZIPK, Control Peptide (ZIPtide, Zip Kinase)

Synthetic substrate peptide (KKLNRTLSFAEP-G) (linear) for ZIPK.\n\nApoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology to DAP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities.\n\nApplications:\nAnalytical Tests: Peptide identity confirmed by MALDI-ToF MS and Amino Acid analysis.\nKinase Assay: Substrate for ZIPK, active.\n\nStorage and Stability: \nLyophilized powder may be stored at 4 degrees C for short-term only. Stable for 12 months at -20 degrees C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.\n\n\n

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SPECIFICATIONS

Catalog Number

Z0550-01A

Size

1mg

Form

Supplied as a lyophilized powder.

Purity

~ 90%

References

1. Kawai, T, et al., Mol. Cell Biol, 18: 1642-1651, 1998.

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