Home  >  Products  >  ZIPK (ZIP Kinase, ZIP, DAP-like Kinase, DLK, Death Associated Kinase 3, Death-associated Protein Kinase 3, DAP Kinase 3, DAPK 3, DAPK-3, DAPK3, EC 2.7.11.1, FLJ36473)
ZIPK (ZIP Kinase, ZIP, DAP-like Kinase, DLK, Death Associated Kinase 3, Death-associated Protein Kinase 3, DAP Kinase 3, DAPK 3, DAPK-3, DAPK3, EC 2.7.11.1, FLJ36473)

ZIPK (ZIP Kinase, ZIP, DAP-like Kinase, DLK, Death Associated Kinase 3, Death-associated Protein Kinase 3, DAP Kinase 3, DAPK 3, DAPK-3, DAPK3, EC 2.7.11.1, FLJ36473)

Cat no: Z0550-21

Supplier: United States Biological
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Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediator of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase (1). ZIP kinase contains an N-terminal kinase domain and a C-terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREB family. ZIP kinase has high sequence homology toDP kinase (death-associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP andDP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues (1). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: HeLa Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Z0550-21
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol 1998;18:1642-51
Additional info: Recognizes human Zip Kinase.

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