Home  >  Products  >  ZNF198 (Zinc Finger MYM-type Protein 2, Fused in Myeloproliferative Disorders Protein, Rearranged in Atypical Myeloproliferative Disorder Protein, Zinc Finger Protein 198, ZMYM2, FIM, RAMP)
ZNF198 (Zinc Finger MYM-type Protein 2, Fused in Myeloproliferative Disorders Protein, Rearranged in Atypical Myeloproliferative Disorder Protein, Zinc Finger Protein 198, ZMYM2, FIM, RAMP)

ZNF198 (Zinc Finger MYM-type Protein 2, Fused in Myeloproliferative Disorders Protein, Rearranged in Atypical Myeloproliferative Disorder Protein, Zinc Finger Protein 198, ZMYM2, FIM, RAMP)

Cat no: Z0741-40E

Supplier: United States Biological
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ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.1-1ug/ml Immunohistochemistry (paraffin): 10ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse skeletal muscle lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Z0741-40E
Reactivities: Human, Mouse, Canine, Non-Human Primate
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Kasyapa et.al Blood 107 (9) 3693-3699 (May 1, 2006) 2. Baumann et.al JBC 278 (18) 16198-16208 (May 2, 2003).
Additional info: Recognizes human Zinc finger protein 198 (ZNF198). Species Crossreactivity: canine, monkey, orangutan. Species sequence homology: mouse, rat, bovine, chicken.

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