ZNFN1A3 (Zinc Finger Protein Subfamily 1A3, Aiolos, IKAROS Family Zinc Finger 3, IKZF3)

IkZF3 is a hemopoietic zinc finger DNA-binding protein that acts as a central regulator of lymphoid differentiation and is implicated in leukemogenesis. It is a 509aa containing nuclear protein and a member of the IKAROS family of C2H2- type zinc-finger proteins and zinc finger protein, subfamily 1A with six C2H2- type zinc-fingers. IkZF3 may form homodimers or heterodimers and is known to interact with IkZF4 and IkZF5. A well known transcription factor, IkZF3, plays an important role in the regulation of B lymphocyte proliferation and differentiation and participates in chromatin remodeling. IkZF3 plays a role in the control of T cell death by regulating the expression of BCL2 in acute lymphoblastic leukemia. Strong expression of IkZF3 is usually detected in peripheral blood leukocytes, spleen, thymus and low expression in liver, small intestine and lung.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

Z0749-10A

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, Bov, Ch/Bird

Form

Supplied as a liquid, 0.025% sodium azide, 50% glycerol.

P Type

Pab

Purity

Serum.

Isotype

IgG

References

1. Wang, JH. et al. Immunity. 9:543-553 (1998). 2. Schmitt, C. et al. Apoptosis. 7:277-284 (2002). 3. Cortes, M. et al. J. Exp. Med. 199:209-219 (2004). 4. Mullighan, CG. et al. Nature. 446:758-764 (2007).

Additional Info

Recognizes human IkZF3, Zinc finger protein Aiolos. Species Crossreactivity: chicken, bovine, equine, mouse, rat, rhesus monkey. Species sequence homology: chimpanzee, equine, xenopus.