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ZNFN1A3 (Zinc Finger Protein Subfamily 1A3, Aiolos, IKAROS Family Zinc Finger 3, IKZF3)

ZNFN1A3 (Zinc Finger Protein Subfamily 1A3, Aiolos, IKAROS Family Zinc Finger 3, IKZF3)

Cat no: Z0749-10A

Supplier: United States Biological
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IkZF3 is a hemopoietic zinc finger DNA-binding protein that acts as a central regulator of lymphoid differentiation and is implicated in leukemogenesis. It is a 509aa containing nuclear protein and a member of the IKAROS family of C2H2- type zinc-finger proteins and zinc finger protein, subfamily 1A with six C2H2- type zinc-fingers. IkZF3 may form homodimers or heterodimers and is known to interact with IkZF4 and IkZF5. A well known transcription factor, IkZF3, plays an important role in the regulation of B lymphocyte proliferation and differentiation and participates in chromatin remodeling. IkZF3 plays a role in the control of T cell death by regulating the expression of BCL2 in acute lymphoblastic leukemia. Strong expression of IkZF3 is usually detected in peripheral blood leukocytes, spleen, thymus and low expression in liver, small intestine and lung. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Z0749-10A
Reactivities: Human, Mouse, Rat, Bovine, Chicken/Bird
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Wang, JH. et al. Immunity. 9:543-553 (1998). 2. Schmitt, C. et al. Apoptosis. 7:277-284 (2002). 3. Cortes, M. et al. J. Exp. Med. 199:209-219 (2004). 4. Mullighan, CG. et al. Nature. 446:758-764 (2007).
Additional info: Recognizes human IkZF3, Zinc finger protein Aiolos. Species Crossreactivity: chicken, bovine, equine, mouse, rat, rhesus monkey. Species sequence homology: chimpanzee, equine, xenopus.

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