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Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)

Zyxin (ZYX, ZYX Protein, Zyxin 2, Zyxin-2, ESP-2, HED-2)

Cat no: Z9800-04B

Supplier: United States Biological
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Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:4000 Western Blot: 0.1-0.3ug/ml ~85kD band observed in Human Peripheral Blood Mononucleocytes lysates (calculated MW of 61.3kD according to NP_003452.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: Z9800-04B
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: HED-2, ESP-2, zyxin, ZYX
References: 1.Li B, Zhuang L, Trueb B, Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. The Journal of biological chemistry 2004 May 279 (19): 20401-10.
Additional info: Recognizes human ZYX. Species sequence homology: canine. Reported variants represent identical protein: NP_003452.1, NP_001010972.1

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