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The human urokinase-type plasminogen activator receptor (uPAR) is a 55-65 kDa, highly glycosylated, GPI-anchored cell surface receptor (the deglycosylated...
CNS white matter is selectively inhibitory for axonal out-growth. Nogo (also designated NI250 and Reticulon 4-A) is an oligodendrocyte-specific member of the...
Glucokinase (also designated hexokinase IV, HXKIV or GCK) plays a key role in the regulation of glucose-induced insulin secretion. GCK is expressed in...
ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease,RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that...
Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs...
G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate...
CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in...
Individuals suffering from Alzheimer's disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression...
Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the...
BRCA 2 is localized to chromosome 13q12 - q13. Loss of heterozygosity of 13q is observed in 25% of sporadic breast tumors, which indicates that BRCA 2 might...
Peropsin is a visual pigment-like protein identified following large-scale sequencing of cDNAs derived from human ocular tissues. Peropsin mRNA is found in...
Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain,...
GPCR GPR136, also known as Opsin 5, is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the...
Melanopsin is an opsin-like protein found in the retinal ganglion cells of mammals. Melanopsin is believed to be part of a secondary optical system that...
Opsins, including Encephalopsin, are members of the superfamily of guanine nucleotide-binding protein (G protein)-coupled receptors, which function through...
The nicotinic acetylcholine receptor (nAChR) is a ligand gated ion channel that mediates neurotransmission at the neuromuscular junction, autonomic ganglia...
Nicotinic acetylcholine receptors(AChRs) are found at the postsynaptic membrane of the neuromuscular junctionand bind acetylcholine molecules, allowing ions...
UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner...
Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are...
In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits...
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